Clonidine hydrochloride is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. Clonidine comes in tablets of 0.1, 0.2, and 0.3 milligrams (mg), and your doctor will try to find the lowest dose of clonidine that works for you. Popular ADHD Drugs & Adderall Replacements. The majority of adhd medication handed out are of the CNS stimulant variety. Ritalin (methylphenidate), Adderall, Adderall XR, Vyvanse, Dexedrine and others are handed out to children and adults alike at alarming rates. Adderall, Adderall XR (extended release), and Mydayis, combination drugs containing four salts of the two enantiomers of amphetamine, are central nervous system (CNS) stimulants of the phenethylamine class. Among the psychiatric disorders that involve norepinephrine (NE), attention deficit hyperactivity disorder (ADHD) is one of the most widespread and clinically significant. There is general agreement that neurological and genetic factors related to However, more than one-half of children with ADHD have psychiatric and developmental comorbidities. For this reason, nonpharmacological interventions should be considered routinely as part of comprehensive ADHD care, with specific goal-setting to improve compliance, academic performance, and quality of life. Clonidine is used to treat high blood pressure, attention deficit hyperactivity disorder (ADHD), drug withdrawal (alcohol, opioids, or smoking), menopausal flushing, diarrhea, and certain pain conditions. Simultaneous use of alcohol or cigarettes and especially street drugs should be avoided. All medications should be avoided if possible in pregnancy. ADHD, or Attention deficit hyperactivity disorder, is the most commonly diagnosed behavioral disorder, characterized by a lack of concentration, impulsivity, and hyperactivity. Clonidine hydrochloride extended-release tablets is indicated for the treatment of attention deficit hyperactivity disorder (ADHD) as monotherapy and as adjunctive therapy to stimulant medications [see Clinical Studies (14)].